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Work at HKU since 2019

  1. Lu, Y.-M., Yan, S., Ti, S.-C., and Zheng, C.* Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration. eLife. 2024 Jul 1;13:RP94583. doi: 10.7554/eLife.94583.

  2. Huang, S.#, Ran, Q.#, Li, X.-M., Bao, X.*, Zheng, C.*, and Li, X.D.* MACSPI Enables Tissue-Selective Proteomic and Interactomic Analysis in Multicellular Organisms. Proc Natl Acad Sci USA. 2024 May 21;121(21):e2319060121 (# co-first author)

  3. Ma, F. and Zheng, C.* Single-cell phylotranscriptomics of developmental and cell type evolution. Trends in Genetics. 2024 Mar 14:S0168-9525(24)00032-5. Review

  4. Wang, C., Yang, M., Liu, D., and Zheng, C.* Metabolic rescue of α-synuclein-induced neurodegeneration through propionate supplementation and intestine-neuron signaling in C. elegans. Cell Reports. 2024 Feb 26;43(3):113865

  5. Ma, F., Lau, C.Y., and Zheng, C.* Young duplicate genes show developmental stage- and cell type-specific expression and function in Caenorhabditis elegans. Cell Genomics. 2024 Jan 10;4(1):100467.

  6. Ma, F. and Zheng, C.* Transcriptome age of individual cell types in Caenorhabditis elegans. Proc Natl Acad Sci USA. 2023 Feb 28;120(9):e2216351120.

  7. Wang, C. and Zheng, C.* Using Caenorhabditis elegans to Model Therapeutic Interventions of Neurodegenerative Diseases Targeting Microbe-Host Interactions. Front Pharmacol. 2022 Apr 28;13:875349. doi: 10.3389/fphar.2022.875349. Review

  8. Lu, Y.M. and Zheng, C.* The Expression and Function of Tubulin Isotypes in Caenorhabditis elegans. Front Cell Dev Biol. 2022 Mar 24;10:860065. doi: 10.3389/fcell.2022.860065. Review

  9. Zheng, C.*, Lee, H.M.T., and Pham, K. Nervous system-wide analysis of Hox regulation of terminal neuronal fate specification in Caenorhabditis elegans. PLOS Genetics. 2022 Feb 28;18(2):e1010092. doi: 10.1371/journal.pgen.1010092. 

  10. Wang, C., Lau, C.Y., Ma, F., and Zheng, C.* Genome-wide screen identifies curli amyloid fibril as a bacterial component promoting host neurodegeneration. Proc Natl Acad Sci USA. 2021 Aug 24;118(34):e2106504118. 

  11. Lu, Y.M. and Zheng, C.* TBA-7 is not a microtubule-destabilizing tubulin. Mol Biol Cell. 2021 Jun 1;32(12):1145-1146. 

  12. Ma, F., Lau, C.Y., and Zheng, C.* Large genetic diversity and strong positive selection in F-box and GPCR genes among the wild isolates of Caenorhabditis elegans. Genome Biol Evol. 2021 May 7;13(5):evab048.

  13. Lee, H.MT.,  Sayegh, N.Y., Gayek, A.S., Jao, S.L.J., Chalfie, M.*, and Zheng, C.* Epistatic, synthetic, and balancing interactions among tubulin missense mutations affecting neurite growth in Caenorhabditis elegans. Mol Biol Cell. 2021 Feb 15;32(4):331-347.

  14. Zheng, C.*, Atlas, E., Lee, H.M.T., Jao, S.L.J., Nguyen, K.C.Q., Hall, D.H., and Chalfie, M.* Opposing effects of an F-box protein and the HSP90 chaperone network on microtubule stability and neurite growth in Caenorhabditis elegans. Development, 2020 Jun 17;147(12).

Other collaborative publications

  1. Song, Y., Zhao, Z., Xu, L., Huang, P., Gao, J., Li, J., Wang, X., Zhou, Y., Wang, J., Zhao, W., Wang, L., Zheng, C., Gao, B., Jiang, L., Liu, K., Guo, Y., Yao, X., Duan, L. Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum. Dev Cell. 2024 Apr 1:S1534-5807(24)00180-1. doi: 10.1016/j.devcel.2024.03.014.

  2. Wang, P., Zhang, G., Xu, Z., Chen, Z., Liu, X., Wang, C., Zheng, C., Wang, J., Zhang, H., and Yan, A. Whole-cell FRET monitoring of transcription factor activities enables functional annotation of signal transduction systems in living bacteria. J Biol Chem. 2022 Jul 12:102258.

  3. He, H., Zhou, M., Qiao, T., Lai, H.M., Ran, Q., Ren, Y.X., Ko, H., Zheng, C., Tsia, K.K., and Wong, K.K.Y. 890-nm-excited SHG and fluorescence imaging enabled by an all-fiber mode-locked laser. Opt Lett. 2022 Jun 1;47(11):2710-2713. doi: 10.1364/OL.455081.

  4. Shi, L., Liu, X., Shi, L., Stinson, H.T., Rowlette, J., Kahl, L.J., Evans, C.R., Zheng, C., Dietrich, L.E.P., and Min ,W. Mid-infrared Metabolic Imaging With Vibrational Probes. Nature Methods, 2020 Jun 29.

Prior to joining HKU in 2018 

  1. Zheng, C., Jin, F.Q., Trippe, B.L., Wu, J., and Chalfie, M. Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans. Development. 2018 Nov 15;145(22).

  2. Shi, L.#, Zheng, C.#, Shen, Y., Chen, Z., Silveira, E.S., Zhang, L., Liu, C., De Sena-Tomas, C., Targoff, K., and Min, W. Optical Imaging of Metabolic Dynamics in Animals. Nat Commun. 2018 Aug 6;9(1):2995. doi: 10.1038/s41467-018-05401-3. (# co-first author)

  3. Zheng, C., Diaz-Cuadros, M., Jao, S.L., Nguyen, K.C., Hall, D.H., and Chalfie, M. Distinct effects of tubulin isotype mutations on neurite growth in Caenorhabditis elegans. Mol Biol Cell. 2017 Oct 15;28(21):2786-2801 (Highlights from MBoC Selection)

  4. Zheng, C., Diaz-Cuadros, M., and Chalfie, M. GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis. Proc Natl Acad Sci U S A. 2016 Jun 21;113(25):6973-8.

  5. Zheng, C. Chalfie, M. Securing Neuronal Cell Fate in C. elegans. Curr Top Dev Biol. 2016;116:167-80 (Invited review)

  6. Zheng, C., Diaz-Cuadros, M., Chalfie, M. Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.  Neuron. 2015 Nov 4;88(3):514-27. (Previewed by Philippidou and Dasen)

  7. Zheng, C., Jin, F.Q., Chalfie, M. Hox Proteins Act as Transcriptional Guarantors to Ensure Terminal Differentiation. Cell Rep. 2015 Nov 17;13(7):1343-52. (Recommended to F1000 prime)

  8. Zheng, C., Diaz-Cuadros, M., Chalfie, M. Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13243-8 (Editor’s Choice by Science Signaling)

  9. Hu, F., Wei, L., Zheng, C., Shen, Y., Min, W. Live-cell vibrational imaging of choline metabolites by stimulated Raman scattering coupled with isotope-based metabolic labeling. Analyst. 2014 Apr 15;139(10):2312-7

  10. Zheng, C., Karimzadegan, S., Chiang, V., Chalfie, M. Histone methylation restrains the expression of subtype-specific genes during terminal neuronal differentiation in Caenorhabditis elegans. PLoS Genet. 2013 Dec;9(12):e1004017

  11. Zheng, C., Feng, J., Lu, D., Wang, P., Xing, S., Coll, JL, Yang, D., Yan, X. A Novel Anti-CEACAM5 Monoclonal Antibody, CC4, Suppresses Colorectal Tumor Growth and Enhances NK Cells-Mediated Tumor Immunity. PLoS One. 2011;6(6):e21146.

  12. Luo, Y.#, Zheng, C.#, Zhang, J., Lu, D., Zhuang, J., Xing, S., Feng, J., Yang, D., Yan, X. Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene. 2012 Jan 19;31(3):306-21. (# co-first author).

  13. Zheng, C., Qiu, Y., Zeng, Q., Zhang, Y., Lu, D., Yang, D., Feng, J., Yan, X. Endothelial CD146 is required for in vitro tumor-induced angiogenesis: The role of a disulfide bond in signaling and dimerization. Int J Biochem Cell Biol. 2009 Nov;41(11):2163-72.

  14. Zhuang, J., Jiang, T., Lu, D., Luo, Y., Zheng, C., Feng, J., Yang, D., Chen, C. and Yan, X. NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radic Biol Med. 2010 Jul 15;49(2):227-36.

  15. Zhang, B., Li, L., Feng, L., Zhang, Y., Zeng, X., Feng, J., Yang, D., Zheng, C., and Yan, X. Elevated Levels of Soluble and Neutrophil CD146 in Active Systemic Vasculitis. Lab Medicine. 2009 May, 40, 351-356

  16. Zhang, Y.#, Zheng, C.#, Zhang, J., Yang D., Feng, J., Lu, D., and Yan, X. Generation and Characterization of a panel of monoclonal antibodies against distinct epitopes of human CD146. Hybridoma (Larchmt). 2008 Oct;27(5):345-52. (# co-first author).

  17. Zhang, S.Y., Ma, X.F., Zheng, C.G., Wang, Y., Cao, X.L., and Tian, W.X. Novel and potent inhibitors of fatty acid synthase derived from catechins and their inhibition on MCF-7 Cells. J Enzyme Inhib Med Chem. 2009 Jun;24(3):623-31

  18. Zhang, S.Y., Zheng, C.G., Yan, X.Y., and Tian, W.X. Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells. Biochem Biophys Res Commu. 2008 Jul 11;371(4):654-8.

  19. Zheng, C., Ren, Z., Wang, H., Zhang, W., Kalvakolanu, D.V., Tian, Z., and Xiao, W. E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res. 2009 Mar 15;69(6):2324-31. (highlighted by Nature China)

  20. Ren, Z., Kang, W., Wang, L., Sun, B., Ma, J., Zheng, C., Sun, J., Tian, Z., Yang, X., Xiao, W. E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation. Mol Cancer. 2014 Apr 17;13:84.

  21. Ma, J., Ren, Z., Ma, Y., Xu, L., Zhao, Y., Zheng, C., Fang, Y., Xue, T., Sun, B., and Xiao, W. Targeted knockdown of EGR-1 inhibits IL-8 production and IL-8-mediated invasion of prostate cancer cells through suppressing EGR-1/NF-kappaB synergy. J Biol Chem. 2009 Dec 11;284(50):34600-6.

  22. Zhang, W., Chen, Y., Wei, H., Zheng, C., Sun, R., and Tian, Z. Anti-apoptotic activity of autocrine IL-22 and therapeutic effects of IL-22-siRNA on human lung cancer xenografts. Clin Cancer Res 2008 Oct 15;14(20):6432-6439

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